MacKeigan Laboratory

Systems Biology

“No great discovery was ever made without a bold guess.”

-Isaac Newton

Our lab focuses on two hallmarks of cancer: deregulating cellular energetics and resisting cell death.These two hallmarks contribute to chemoresistance, a significant problem in the cancer field, and are regulated by mTOR signaling. We seek a “systems level” understanding of the network encompassing cell metabolism, autophagy, and the mTOR signaling pathway. Our research spans a variety of cancers and technologies, and we also use our tumor biology expertise and pathway knowledge to study tuberous sclerosis complex. All of our research projects have one common goal—to identify novel therapeutic targets.